Recombinant Human FGFR4 protein, His-Avi-tagged

• Cat.No.: FGFR4-140H
• Product Overview: Recombinant Human FGFR4 Protein is expressed from mammalian with a His tag and Avi Tag at the C-terminal. It contains Leu22-Asp369.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: It contains Leu22-Asp369.
• Description: Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
• Form: Supplied as 0. 22um filtered solution in 20mMPB,150mMNaCl, pH 7. 4.
• Molecular Mass: The protein has a predicted MW of 41. 4 kDa. Due to glycosylation, the protein migrates to 60-75 KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0. 01 EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ]
• Official Symbol: FGFR4
• Synonyms: CD334 antigen; CD334; EC 2. 7. 10; EC 2. 7. 10. 1; FGF R4; FGFR4; FGFR-4; fibroblast growth factor receptor 4; JTK2hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; TKF; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• MIM: 134935
• UniProt ID: P22455