Recombinant Human FGFR4, GST-tagged, Active

• Cat.No.: FGFR4-316H
• Product Overview: Recombinant human FGFR4 (460-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. MW=65 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 460-end a.a.
• Description: FGFR4 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR4 preferentially binds acidic fibroblast growth factor and is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4 gene expression is up-regulated in doxorubicin-treated, apoptosis-resistant cancer cell clones. Ectopic expression of FGFR4 in cancer cells leads to reduced apoptosis sensitivity on treatment with doxorubicin or cyclophosphamide, whereas knockdown of endogenous FGFR4 expression in breast cancer cell lines has the opposite effect.
• Sequence: 460-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: FGFR4 fibroblast growth factor receptor 4 [ Homo sapiens ]
• Synonyms: FGFR4; fibroblast growth factor receptor 4; TKF; JTK2; CD334; MGC20292; OTTHUMP00000161430; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; tyrosine kinase related to fibroblast growth factor receptor; EC 2.7.10.1; FGFR-4; CD334 antigen
• Gene ID: 2264
• mRNA Refseq: NM_002011
• Protein Refseq: NP_002002
• UniProt ID: P22455
• Chromosome Location: 5q33-qter
• MIM: 134935
• Pathway: Endocytosis; MAPK signaling pathway; Regulation of actin cytoskeleton; Signaling by FGFR
• Function: ATP binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity