Recombinant Human FGD1, GST-tagged

• Cat.No.: FGD1-12857H
• Product Overview: Recombinant Human FGD1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-351a.a.
• Description: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FGD1 FYVE, RhoGEF and PH domain containing 1 [ Homo sapiens ]
• Official Symbol: FGD1
• Synonyms: FGD1; FYVE, RhoGEF and PH domain containing 1; faciogenital dysplasia (Aarskog Scott syndrome) , FGDY; FYVE, RhoGEF and PH domain-containing protein 1; ZFYVE3; rho/Rac GEF; faciogenital dysplasia 1 protein; zinc finger FYVE domain-containing protein 3; rho/Rac guanine nucleotide exchange factor FGD1; AAS; FGDY; MRXS16
• Gene ID: 2245
• mRNA Refseq: NM_004463
• Protein Refseq: NP_004454
• MIM: 300546
• UniProt ID: P98174
• Chromosome Location: Xp11.21
• Pathway: Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of CDC42 activity, organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem
• Function: Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; metal ion binding; small GTPase binding