Recombinant Human FCGRT Protein

• Cat.No.: FCGRT-038H
• Product Overview: Recombinant human IgG1 Fc (rhIgG1 Fc) Glu99 - Lys330 (Accession # AAC82527.1) was expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Protein Length: 99-330 a.a.
• Description: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
• Molecular Mass: rhIgG1 Fc, a 232 amino acids protein, has a calculated MW of 26 kDa. DTT-reduced protein migrates as 35 kDa protein due to glycosylation.
• Endotoxin: Less than 1.0 EU per 0.5µg of the human IgG1 Fc by the LAL method.
• Purity: >98% as determined by SDS-PAGE of 20 µg reduced rhIgG1 Fc. All lots are greater than 98% pure.
• Notes: Research Use Only. Not for use in diagnostic or therapeutic procedures.
• Storage: Store at -20 centigrade in lyophilized state after receipt. For long term storage, upon reconstitution rhIgG1 Fc should be aliquot and store at -20 centigrade or -8 centigrade centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Bulk protein in a 0.22 µm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.

Gene Information

• Gene Name: FCGRT Fc fragment of IgG, receptor, transporter, alpha [ Homo sapiens ]
• Official Symbol: FCGRT
• Synonyms: FCGRT; Fc fragment of IgG, receptor, transporter, alpha; IgG receptor FcRn large subunit p51; alpha chain; FCRN; FcRn alpha chain; neonatal Fc receptor; neonatal Fc-receptor for Ig; IgG Fc fragment receptor transporter alpha chain; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; alpha-chain
• Gene ID: 2217
• mRNA Refseq: NM_001136019
• Protein Refseq: NP_001129491
• MIM: 601437
• UniProt ID: P55899