Recombinant Human FBXW2, GST-tagged

Cat.No. : FBXW2-12810H
Product Overview : Recombinant Human FBXW2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Availability March 14, 2025
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Species : Human
Source : E.coli
Tag : GST
Protein Length : N-term-314a.a.
Description : F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name FBXW2 F-box and WD repeat domain containing 2 [ Homo sapiens ]
Official Symbol FBXW2
Synonyms FBXW2; F-box and WD repeat domain containing 2; F box and WD 40 domain protein 2; F-box/WD repeat-containing protein 2; FBW2; Fwd2; Md6; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; MGC117371;
Gene ID 26190
mRNA Refseq NM_012164
Protein Refseq NP_036296
MIM 609071
UniProt ID Q9UKT8
Chromosome Location 9q34
Pathway Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein folding, organism-specific biosystem; Wnt Signaling Pathway, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem;
Function ubiquitin-protein ligase activity;

Not For Human Consumption!

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