Recombinant Human FBXW2, GST-tagged

• Cat.No.: FBXW2-12810H
• Product Overview: Recombinant Human FBXW2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-314a.a.
• Description: F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FBXW2 F-box and WD repeat domain containing 2 [ Homo sapiens ]
• Official Symbol: FBXW2
• Synonyms: FBXW2; F-box and WD repeat domain containing 2; F box and WD 40 domain protein 2; F-box/WD repeat-containing protein 2; FBW2; Fwd2; Md6; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; MGC117371
• Gene ID: 26190
• mRNA Refseq: NM_012164
• Protein Refseq: NP_036296
• MIM: 609071
• UniProt ID: Q9UKT8
• Chromosome Location: 9q34
• Pathway: Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein folding, organism-specific biosystem; Wnt Signaling Pathway, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem
• Function: ubiquitin-protein ligase activity