Recombinant Human FBXW2, GST-tagged
Cat.No. : | FBXW2-12810H |
Product Overview : | Recombinant Human FBXW2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | March 14, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | N-term-314a.a. |
Description : | F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | FBXW2 F-box and WD repeat domain containing 2 [ Homo sapiens ] |
Official Symbol | FBXW2 |
Synonyms | FBXW2; F-box and WD repeat domain containing 2; F box and WD 40 domain protein 2; F-box/WD repeat-containing protein 2; FBW2; Fwd2; Md6; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; MGC117371; |
Gene ID | 26190 |
mRNA Refseq | NM_012164 |
Protein Refseq | NP_036296 |
MIM | 609071 |
UniProt ID | Q9UKT8 |
Chromosome Location | 9q34 |
Pathway | Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein folding, organism-specific biosystem; Wnt Signaling Pathway, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; |
Function | ubiquitin-protein ligase activity; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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