Recombinant Human FBXO18, His-tagged

• Cat.No.: FBXO18-12787H
• Product Overview: Recombinant Human FBXO18 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 693-1043a.a.
• Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FBXO18 F-box protein, helicase, 18 [ Homo sapiens ]
• Official Symbol: FBXO18
• Synonyms: FBXO18; F-box protein, helicase, 18; F box only protein 18; F-box only protein 18; FBH1; Fbx18; FLJ14590; F-box DNA helicase 1; F-box only protein, helicase, 18; MGC131916; MGC141935; MGC141937
• Gene ID: 84893
• mRNA Refseq: NM_032807
• Protein Refseq: NP_116196
• MIM: 607222
• UniProt ID: Q8NFZ0
• Chromosome Location: 10p15.1
• Function: ATP binding; ATP-dependent DNA helicase activity; DNA binding; helicase activity; hydrolase activity; nucleotide binding