Recombinant Human FBLN1

• Cat.No.: FBLN1-28904TH
• Product Overview: Recombinant full length Human Fibulin 1 with N terminal proprietary tag; Predicted MWt 101.2 kDa inclusive of tag.

Specification

• Description: Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3 end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
• Protein length: 683 amino acids
• Molecular Weight: 101.200kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MERAAPSRRVPLQLLLLGGLALLAAGVDADVLLEACCADG HRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCAT GISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQ AQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQE TDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSF RCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQ NTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCP IGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCE DINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCE DIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNG SNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY RRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAP AVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSG VVALTKPVPEPRDLLLTVKMDLSRHGTVSSFVAKLFIFVS AEL
• Sequence Similarities: Belongs to the fibulin family.Contains 3 anaphylatoxin-like domains.Contains 9 EGF-like domains.
• Tag: Non

Gene Information

• Gene Name: FBLN1 fibulin 1 [ Homo sapiens ]
• Official Symbol: FBLN1
• Synonyms: FBLN1; fibulin 1; fibulin-1; FBLN
• Gene ID: 2192
• mRNA Refseq: NM_001996
• Protein Refseq: NP_001987
• MIM: 135820
• Uniprot ID: P23142
• Chromosome Location: 22q13.31
• Function: calcium ion binding; extracellular matrix structural constituent; peptidase activator activity