Recombinant Human FASTK, GST-tagged

• Cat.No.: FASTK-801H
• Product Overview: Recombinant full-length human FASTK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: FASTK or Fas-Activated Serine/Threonine Kinase is a member of the serine/ thre- onine protein kinase family that becomes rapidly activated during Fas-mediatedapoptosis in Jurkat cells and in response to Fas receptor ligation. FASTK interacts with and phosphorylates TIA1 which is an apoptosis-promoting nuclear RNA- binding protein. FAST K influences alternative pre-mRNA splicing by affecting the activity of TIA-1/TIAR. FASTK is a strong inducer of lymphocyte apoptosis. FASTK is the component of the molecular cascade that involved in FAS-mediated apoptosis. FASTK is highly expreesed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
• Predicted MolecularMass: ~84 kDa
• Formulation: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• SpecificActivity: 1.0 nmol/min/mg
• Applications: WB
• Purity: >70%
• Concentration: 0.05 μg/μl
• Stability& Storage: Store product at –70°C. For optimal storage, aliquottarget into smaller quantities after centrifugation and store at recommended temperature. For most favorableperformance, avoid repeated handling and multiple freeze/thaw cycles.
• OfficialSymbol: FASTK

Gene Information

• Gene Name: FASTK Fas-activated serine/threonine kinase [ Homo sapiens ]
• Synonyms: FASTK; Fas-activated serine/threonine kinase; FAST; fas-activated serine/threonine kinase; FAST kinase; EC 2.7.11.8; Fas activated serine threonine kinase; FASTK_HUMAN; FLJ13079
• Gene ID: 10922
• mRNA Refseq: NM_006712
• Protein Refseq: NM_006712
• MIM: 606965
• UniProt ID: Q14296
• Chromosome Location: 7q35
• Function: ATP binding; Fas-activated serine/threonine kinase activity; protein binding; protein serine/threonine kinase activity