Recombinant Human FANCI, GST-tagged

• Cat.No.: FANCI-12740H
• Product Overview: Recombinant Human FANCI protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-252a.a.
• Description: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FANCI Fanconi anemia, complementation group I [ Homo sapiens ]
• Official Symbol: FANCI
• Synonyms: FANCI; Fanconi anemia, complementation group I; KIAA1794; Fanconi anemia group I protein; FLJ10719
• Gene ID: 55215
• mRNA Refseq: NM_001113378
• Protein Refseq: NP_001106849
• MIM: 611360
• UniProt ID: Q9NVI1
• Chromosome Location: 15q26.1
• Pathway: DNA Repair, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Regulation of the Fanconi anemia pathway, organism-specific biosystem
• Function: protein binding