Recombinant Human FA2H, His-tagged

• Cat.No.: FA2H-12628H
• Product Overview: Recombinant Human FA2H protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-164a.a.
• Description: This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FA2H fatty acid 2-hydroxylase [ Homo sapiens ]
• Official Symbol: FA2H
• Synonyms: FA2H; fatty acid 2-hydroxylase; fatty acid hydroxylase domain containing 1 , FAXDC1, spastic paraplegia 35 (autosomal recessive) , SPG35; FAAH; fatty acid hydroxylase; FLJ25287; fatty acid alpha-hydroxylase; fatty acid hydroxylase domain containing 1; spastic paraplegia 35 (autosomal recessive); FAH1; SCS7; SPG35; FAXDC1
• Gene ID: 79152
• mRNA Refseq: NM_024306
• Protein Refseq: NP_077282
• MIM: 611026
• UniProt ID: Q7L5A8
• Chromosome Location: 16q23
• Function: heme binding; metal ion binding; oxidoreductase activity