Recombinant Human EXOSC7, His-tagged

• Cat.No.: EXOSC7-261H
• Product Overview: EXOSC7, 1-291aa, Human, His tag, E.coli

Specification

• Description: EXOSC7 belongs to the RNase PH family and is a component of the RNA exosome complex. Recombinant human EXOSC7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
• Molecular Mass: 34.2 kDa (314aa) confirmed by MALDI-TOF
• Protein length: 1-291aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMASVTLS EAEKVYIVHG VQEDLRVDGR GCEDYRCVEV ETDVVSNTSG SARVKLGHTD ILVGVKAEMG TPKLEKPNEG YLEFFVDCSA SATPEFEGRG GDDLGTEIAN TLYRIFNNKS SVDLKTLCIS PREHCWVLYV DVLLLECGGN LFDAISIAVK AALFNTRIPR VRVLEDEEGS KDIELSDDPY DCIRLSVENV PCIVTLCKIG YRHVVDATLQ EEACSLASLL VSVTSKGVVT CMRKVGKGSL DPESIFEMME TGKRVGKVLH ASLQSVVHKE ESLGPKRQKV GFLG
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: EXOSC7 exosome component 7 [ Homo sapiens ]
• Official Symbol: EXOSC7
• Synonyms: EXOSC7; exosome component 7; exosome complex component RRP42; EAP1; hRrp42p; KIAA0116; p8; RRP42; Rrp42p; exosome complex exonuclease RRP42; ribosomal RNA-processing protein 42; FLJ26543
• Gene ID: 23016
• mRNA Refseq: NM_015004
• Protein Refseq: NP_055819
• MIM: 606488
• UniProt ID: Q15024
• Chromosome Location: 3p21.32
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem
• Function: 3-5-exoribonuclease activity; RNA binding; NOT exoribonuclease activity; protein binding