Recombinant Human ESR2, GST-tagged

• Cat.No.: ESR2-12558H
• Product Overview: Recombinant Human ESR2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-323a.a.
• Description: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ESR2 estrogen receptor 2 (ER beta) [ Homo sapiens ]
• Official Symbol: ESR2
• Synonyms: ESR2; estrogen receptor 2 (ER beta); estrogen receptor beta; Erb; NR3A2; estrogen receptor beta 4; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; nuclear receptor subfamily 3 group A member 2; ESRB; ESTRB; ER-BETA; ESR-BETA
• Gene ID: 2100
• mRNA Refseq: NM_001040275
• Protein Refseq: NP_001035365
• MIM: 601663
• UniProt ID: Q92731
• Chromosome Location: 14q21-q22
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; Ovarian Infertility Genes, organism-specific biosystem; Plasma membrane estrogen receptor signaling, organism-specific biosystem
• Function: DNA binding; core promoter sequence-specific DNA binding; enzyme binding; estrogen receptor activity; estrogen response element binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; pro