Recombinant Human EPHA4

• Cat.No.: EPHA4-26439TH
• Product Overview: Recombinant fragment corresponding to amino acids 610-887 of human Eph receptor A4 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 58kDa.

Specification

• Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
• Tissue specificity: Ubiquitous.
• Biological activity: Specific activity of Eph receptor A4 was determined to be 83 nmol/min/mg as per activity assay protocol.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain.
• Tag: Non
• Protein length: 610-887 a.a.

Gene Information

• Gene Name: EPHA4 EPH receptor A4 [ Homo sapiens ]
• Official Symbol: EPHA4
• Synonyms: EPHA4; EPH receptor A4; EphA4 , TYRO1; ephrin type-A receptor 4; Hek8
• Gene ID: 2043
• mRNA Refseq: NM_004438
• Protein Refseq: NP_004429
• MIM: 602188
• Uniprot ID: P54764
• Chromosome Location: 2q36.3
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHA forward signaling, organism-specific biosystem; EphrinA-EPHA pathway, organism-specific biosystem
• Function: ATP binding; DH domain binding; GPI-linked ephrin receptor activity; PH domain binding; ephrin receptor binding