Recombinant Human ENPP2 Protein, His-tagged

• Cat.No.: ENPP2-076H
• Product Overview: Active recombinant C-terminal histidine-tagged human ENPP2 protein (36-863) was expressed using a baculovirus overexpression system in Sf21 cells.

Specification

• Description: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: Insect cell
• Species: Human
• Tag: His
• Molecular Mass: 98.8 kDa
• Protein length: 36-863
• Purity: ≥90% as determined by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to produce 1 μmol of p-nitrophenol per minute at 37 centigrade in 50 mM Tris-HCl, pH 9.0, containing bis-nitrophenol phosphate.
• Stability: ≥ 9 months
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol

Gene Information

• Gene Name: ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Homo sapiens (human) ]
• Official Symbol: ENPP2
• Synonyms: ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2; ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; autotaxin-t; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D; EC 3.1.4.39
• Gene ID: 5168
• mRNA Refseq: NM_006209
• Protein Refseq: NP_006200
• MIM: 601060
• UniProt ID: Q13822