Recombinant Human EIF3G Protein (P2-N320), His tagged

• Cat.No.: EIF3G-1057H
• Product Overview: Recombinant Human 6His-TEV-GG-eIF3g(P2-N320 end) Protein was expressed in E. coli.

Specification

• Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: P2-N320
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris (pH 8.0), 150mM NaCl, 5% glycerol, 5mM DTT
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: EIF3G eukaryotic translation initiation factor 3, subunit G [ Homo sapiens (human) ]
• Official Symbol: EIF3G
• Synonyms: EIF3G; eukaryotic translation initiation factor 3, subunit G; EIF3S4, eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa; eukaryotic translation initiation factor 3 subunit G; eIF3 delta; eIF3 p44; eIF3g; eIF3 p42; eIF-3-delta; eIF-3 RNA-binding subunit; eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3 RNA-binding subunit; eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa; eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD); EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
• Gene ID: 8666
• mRNA Refseq: NM_003755
• Protein Refseq: NP_003746
• MIM: 603913
• UniProt ID: O75821