Recombinant Human EIF3F Protein (A2-L357), GST tagged

• Cat.No.: EIF3F-0310H
• Product Overview: Recombinant Human GST-TEV-GG-EIF3S5(A2-L357 end) Protein was expressed in E. coli.

Specification

• Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Liquid
• Protein length: A2-L357
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: EIF3F eukaryotic translation initiation factor 3, subunit F [ Homo sapiens (human) ]
• Official Symbol: EIF3F
• Synonyms: EIF3F; eukaryotic translation initiation factor 3, subunit F; EIF3S5, eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3 subunit F; eIF3 epsilon; eIF3 p47; eIF3f; eIF3-epsilon; eIF-3-epsilon; eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); EIF3S5; eIF3-p47
• Gene ID: 8665
• mRNA Refseq: NM_003754
• Protein Refseq: NP_003745
• MIM: 603914
• UniProt ID: O00303