Recombinant Human EHMT1 Protein, GST-tagged

• Cat.No.: EHMT1-006H
• Product Overview: Recombinant Human EHMT1 protein with a N-terminal GST-tag was expressed in E. coli

Specification

• Description: The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: 60.3 kDa
• Purity: ≥95% estimated by SDS-PAGE
• Unit Definition: One unit is defined as the amount of enzyme required to transfer one methyl group to Histone H3 per minute as determined using 100 µM Histone H3 (1-21) peptide at 37 centigrade using Methyltransferase Colorimetric Assay Kit.
• Stability: ≥ 545 days
• Storage: -80 centigrade
• Shipping: Dry ice in continental US, may vary elsewhere.

Gene Information

• Gene Name: EHMT1 euchromatic histone lysine methyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: EHMT1
• Synonyms: EHMT1; euchromatic histone lysine methyltransferase 1; GLP; GLP1; KMT1D; KLEFS1; FP13812; EHMT1-IT1; EUHMTASE1; Eu-HMTase1; histone-lysine N-methyltransferase EHMT1; EHMT1 intronic transcript 1; G9a-like protein 1; H3-K9-HMTase 5; euchromatic histone-lysine N-methyltransferase 1; histone H3-K9 methyltransferase 5; histone-lysine N-methyltransferase, H3 lysine-9 specific 5; lysine N-methyltransferase 1D; EC 2.1.1.43
• Gene ID: 79813
• mRNA Refseq: NM_024757
• Protein Refseq: NP_079033
• MIM: 607001
• UniProt ID: Q9H9B1