Recombinant Human EGFR Protein, His-tagged

• Cat.No.: EGFR-01H
• Product Overview: Mouse myeloma cell line, NS0-derived human EGFR protein Leu25-Ser378 (Asn273Lys), with a C-terminal 6-His tag.

Specification

• Species: Human
• Source: NS0
• Tag: His
• Protein Length: 25-378 a.a.
• Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
• Form: Lyophilized from a 0.2 μm filtered solution in PBS.
• Molecular Mass: Predicted Molecular Mass: 39 kDa
  SDS-PAGE: 65-80 kDa, reducing conditions
• N-terminal Sequence Analysis: Leu25
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >95%
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 250 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
• Official Symbol: EGFR
• Synonyms: ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2
• Gene ID: 1956
• mRNA Refseq: NM_001346941
• Protein Refseq: NP_001333870
• MIM: 131550
• UniProt ID: P00533