Recombinant Human EGFR Protein, His\Avi-tagged

• Cat.No.: EGFR-179H
• Product Overview: Biotinylated Recombinant Human Epidermal Growth Factor Receptor/Receptor Tyrosine Protein KinaseErbB1 is produced by our Mammalian expression system and the target gene encoding Leu25-Ser378 is expressed with a 6His, Avi tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His&Avi
• ProteinLength: 25-378 a.a.
• Description: The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.
• Form: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• AA Sequence: Leu25-Ser378
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: EGFR epidermal growth factor receptor [ Homo sapiens (human) ]
• Official Symbol: EGFR
• Synonyms: Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptortyrosine-protein kinase erbB-1; ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2
• Gene ID: 1956
• mRNA Refseq: NM_001346941.2
• Protein Refseq: NP_001333870.1
• MIM: 131550
• UniProt ID: P00533