Recombinant Human EGFR protein, His-Avi-tagged

• Cat.No.: EGFR-258H
• Product Overview: Human EGFR/HER1 Protein is expressed from mammalian with a His tag and Avi tag at the C-terminal. It contains Leu 25 - Ser645.

Specification

• Species: Human
• Source: HEK293
• Tag: Avi&His
• Protein Length: It contains Leu 25 - Ser645.
• Description: The epidermal growth factor receptor is a transmembrane protein that is a receptor for members of the epidermal growth factor family of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR, HER2/neu, Her 3 and Her 4. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
• Form: Supplied as 0. 22um filtered solution in PBS (pH 7. 4).
• Molecular Mass: The protein has a predicted MW of 71. 5 kDa. Due to glycosylation, the protein migrates to 85- 110KDa based on Bis-Tris PAGE result.
• Endotoxin: Less than 0. 05EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: EGFR epidermal growth factor receptor [ Homo sapiens ]
• Official Symbol: EGFR
• Synonyms: ErbB; ErbB1; HER1; HER-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2. 7. 10; EC 2. 7. 10. 1; EGF R; EGFR; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog); epidermal growth factor receptor; ERBB1PIG61;mENA; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
• Gene ID: 1956
• mRNA Refseq: NM_005228
• Protein Refseq: NP_005219
• MIM: 131550
• UniProt ID: P00533