Recombinant Human EARS2 Protein, His-tagged

• Cat.No.: EARS2-161H
• Product Overview: Recombinant Human EARS2, transcript variant 1, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants.
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 58.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) [ Homo sapiens ]
• Official Symbol: EARS2
• Synonyms: EARS2; glutamyl-tRNA synthetase 2, mitochondrial (putative); probable glutamate--tRNA ligase, mitochondrial; glutamate tRNA ligase 2; mitochondrial (putative); KIAA1970; MSE1; gluRS; glutamate--tRNA ligase; glutamate tRNA ligase 2, mitochondrial; probable glutamyl-tRNA synthetase, mitochondrial
• Gene ID: 124454
• mRNA Refseq: NM_001083614
• Protein Refseq: NP_001077083
• MIM: 612799
• UniProt ID: Q5JPH6