EARS2
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Official Full Name
glutamyl-tRNA synthetase 2, mitochondrial (putative) -
Overview
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class-I aminoacyl-tRNA synthetase family and catalyzes the attachment of glutamate to tRNA(Glu). Alternative splicing results in multiple transcript variants. -
Synonyms
EARS2;glutamyl-tRNA synthetase 2, mitochondrial (putative);probable glutamyl-tRNA synthetase, mitochondrial;glutamate tRNA ligase 2;mitochondrial (putative);KIAA1970;MSE1;AL024049;mKIAA1970;3230401I01Rik;EARS 2;GluRS;Glutamate--tRNA ligase;Probable glutamyl tRNA synthetase, mitochondrial;RGD1307904;glutamate tRNA ligase 2, mitochondrial
Recombinant Proteins
- Human
- Chicken
- Cynomolgus
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
EARS2 involved in several pathways and played different roles in them. We selected most pathways EARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis,Gene Expression,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ACAA1,Amy1,NDUFC1,EXTL3,GALNT4,PTGES,FUT9,AGPHD1,GMPPB,GM5506 |
| Aminoacyl-tRNA biosynthesis | RARS2,PET112L,NARS2,DARS2,QRSL1,GARS,AARS2,YARS2,HARS2,TARS |
| Gene Expression | ZNF480,ZNF471,SKI,ZNF443,GTF3C4,ZNF223,ZNF225,ZKSCAN1,EED,NR2C1 |
| tRNA Aminoacylation | AARS,EEF1E1,AIMP2,FARSB,AIMP1,FARS2,WARS2,KARS,DARS,MADD |
| Mitochondrial tRNA aminoacylation | WARS2,KARS,FARS2 |
| Porphyrin and chlorophyll metabolism | HMOX1,UGT1A1,UGT1A7,ALAS2,HMOX2A,MMAB,CPOX,HCCS,UROS,UGT1A3 |
Protein Function
EARS2 has several biochemical functions, for example, ATP binding,glutamate-tRNA ligase activity,glutamate-tRNA(Gln) ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EARS2 itself. We selected most functions EARS2 had, and list some proteins which have the same functions with EARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | EEF1A1,PSTK,AIMP1,ALKBH8,MADD,METTL1,NSUN2,THG1L,TYW5,FARS2 |
| glutamate-tRNA ligase activity | EPRS |
| ATP binding | PRPF4BA,BAT1,CSF1RA,ROCK2A,HNRNPU,DDX20,MYHZ2,RYK,NAV3,cka1 |
Interacting Protein
EARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EARS2.
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References
- Guo, LT; Helgadottir, S; et al. Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor. NUCLEIC ACIDS RESEARCH 40:7967-7974(2012).
