EARS2

  • Official Full Name

    glutamyl-tRNA synthetase 2, mitochondrial (putative)

  • Overview

    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class-I aminoacyl-tRNA synthetase family and catalyzes the attachment of glutamate to tRNA(Glu). Alternative splicing results in multiple transcript variants.

  • Synonyms

    EARS2;glutamyl-tRNA synthetase 2, mitochondrial (putative);probable glutamyl-tRNA synthetase, mitochondrial;glutamate tRNA ligase 2;mitochondrial (putative);KIAA1970;MSE1;AL024049;mKIAA1970;3230401I01Rik;EARS 2;GluRS;Glutamate--tRNA ligase;Probable glutamyl tRNA synthetase, mitochondrial;RGD1307904;glutamate tRNA ligase 2, mitochondrial

Recombinant Proteins

  • Human
  • Chicken
  • Cynomolgus
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
EARS2-12255H Recombinant Human EARS2, GST-tagged E.coli Human GST C-term-351a.a.
EARS2-161H Recombinant Human EARS2 Protein, His-tagged E.coli Human His
EARS2-3016H Recombinant Human EARS2 Protein, GST-tagged Wheat Germ Human GST
EARS2-3114C Recombinant Chicken EARS2 Mammalian Cell Chicken His
EARS2-476C Recombinant Cynomolgus EARS2 Protein, His-tagged Mammalian Cell Cynomolgus His
EARS2-4952M Recombinant Mouse EARS2 Protein Mammalian Cell Mouse His
EARS2-524HCL Recombinant Human EARS2 cell lysate Human Non
Ears2-1394M Recombinant Mouse Ears2 Protein, His-tagged E.coli Mouse His Ser286-Ser523
EARS2-1395H Recombinant Human EARS2 Protein, His-tagged E.coli Human His Gly247-Ser523
EARS2-1749H Recombinant Human EARS2 Protein (Gly247-Gln496), N-His tagged E.coli Human His Gly247-Gln496
EARS2-222C Recombinant Cynomolgus Monkey EARS2 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
EARS2-222C-B Recombinant Cynomolgus Monkey EARS2 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
EARS2-2612M Recombinant Mouse EARS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
EARS2-2612M-B Recombinant Mouse EARS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EARS2-4132HF Recombinant Full Length Human EARS2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 523 amino acids

    Involved Pathway

    EARS2 involved in several pathways and played different roles in them. We selected most pathways EARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis,Gene Expression,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression SLC38A8,COX14,ZNF133,ZNF669,CSTF1,SUPT5H,PUS7,TAF1D,NR2F6,MANEA
    Metabolic pathways BHMT,AMY2A4,ALDH7A1,ALOX5,ATP6V1G2,NDUFS8,TST,PIK3C3,B3GNT5,MTMR7
    Mitochondrial tRNA aminoacylation WARS2,FARS2,KARS
    Porphyrin and chlorophyll metabolism ALAS2,UGT2A2,HCCSA.1,GUSB,HMOX2A,UROS,HMOX1A,UGT2A1,COX15,UGT1AB
    Aminoacyl-tRNA biosynthesis TARSL2,DARS,FARSA,CARS,NARS,QRSL1,SARS,PARS2,HARS,YARS
    tRNA Aminoacylation FARS2,MADD,FARSB,EEF1E1,WARS2,DARS,AARS,AIMP1,KARS,AIMP2

    Protein Function

    EARS2 has several biochemical functions, for example, ATP binding,glutamate-tRNA ligase activity,glutamate-tRNA(Gln) ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EARS2 itself. We selected most functions EARS2 had, and list some proteins which have the same functions with EARS2. You can find most of the proteins on our site.

    Function Related Protein
    glutamate-tRNA ligase activity EPRS
    ATP binding ATP1A3A,PDGFRA,CMPK2,SRPK1,PFKP,LMTK2,ARAF,SUCLA2,AK7,CKMT1
    tRNA binding CTU2,ALKBH8,PTCD1,EIF2A,YARS2,XPOT,AARS,RARS,TERT,MARS

    Interacting Protein

    EARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EARS2.

    Resources

    References

    • Guo, LT; Helgadottir, S; et al. Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor. NUCLEIC ACIDS RESEARCH 40:7967-7974(2012).

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