Recombinant Human E2F1, GST-tagged
Cat.No. : | E2F1-12245H |
Product Overview : | Recombinant Human E2F1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | C-term-350a.a. |
Description : | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | E2F1 E2F transcription factor 1 [ Homo sapiens ] |
Official Symbol | E2F1 |
Synonyms | E2F1; E2F transcription factor 1; RBBP3; transcription factor E2F1; RBP3; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding protein 3; retinoblastoma-associated protein 1; E2F-1; RBAP1; |
Gene ID | 1869 |
mRNA Refseq | NM_005225 |
Protein Refseq | NP_005216 |
MIM | 189971 |
UniProt ID | Q01094 |
Chromosome Location | 20q11 |
Pathway | Activation of BH3-only proteins, organism-specific biosystem; Activation of NOXA and translocation to mitochondria, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; |
Function | DNA binding; DNA binding; core promoter binding; cyclin-dependent protein kinase activity; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor acti |
◆ Recombinant Proteins | ||
E2F1-5332H | Recombinant Human E2F1 protein, His-tagged | +Inquiry |
E2F1-9882HFL | Recombinant Full Length Human E2F1, Flag-tagged | +Inquiry |
E2F1-6772C | Recombinant Chicken E2F1 | +Inquiry |
E2F1-3002H | Recombinant Human E2F1 Protein, GST-tagged | +Inquiry |
E2F1-12245H | Recombinant Human E2F1, GST-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
E2F1-6743HCL | Recombinant Human E2F1 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All E2F1 Products
Required fields are marked with *
My Review for All E2F1 Products
Required fields are marked with *
0
Inquiry Basket