Recombinant Human DYRK1B Protein (A2-S629), GST tagged

• Cat.No.: DYRK1B-0397H
• Product Overview: Recombinant Human GST-TEV-GG-DYRK1b(A2-S629 end) Protein was expressed in Insect cell.

Specification

• Description: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein length: A2-S629
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B [ Homo sapiens (human) ]
• Official Symbol: DYRK1B
• Synonyms: DYRK1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; dual specificity tyrosine-phosphorylation-regulated kinase 1B; minibrain related kinase; MIRK; mirk protein kinase; minibrain-related kinase
• Gene ID: 9149
• mRNA Refseq: NM_004714
• Protein Refseq: NP_004705
• MIM: 604556
• UniProt ID: Q9Y463