Recombinant Human DUSP10, GST-tagged

Cat.No. : DUSP10-12203H
Product Overview : Recombinant Human DUSP10 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Availability March 14, 2025
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Species : Human
Source : E.coli
Tag : GST
Protein Length : C-term-200a.a.
Description : Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name DUSP10 dual specificity phosphatase 10 [ Homo sapiens ]
Official Symbol DUSP10
Synonyms DUSP10; dual specificity phosphatase 10; dual specificity protein phosphatase 10; MKP 5; MKP5; map kinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 5; MKP-5;
Gene ID 11221
mRNA Refseq NM_007207
Protein Refseq NP_009138
MIM 608867
UniProt ID Q9Y6W6
Chromosome Location 1q41
Pathway ATF-2 transcription factor network, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Regulation of p38-alpha and p38-beta, organism-specific biosystem;
Function MAP kinase tyrosine/serine/threonine phosphatase activity; hydrolase activity; phosphoprotein phosphatase activity; protein tyrosine phosphatase activity;

Not For Human Consumption!

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