Recombinant Human DTYMK, His-tagged

• Cat.No.: DTYMK-3562H
• Product Overview: Recombinant human DTYMK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-212aa).

Specification

• Cat. No.: DTYMK-3562H
• Description: DTYMK is also known as thymidylate kinase family and is involved in pyrimidine metabolism. Specifically, DTYMK catalyzes the ATP-dependent conversion of dTMP (deoxythymidine monophosphate) to dTDP (deoxythymidine diphosphate), which then functions as one of the four nucleotides in DNA. Via its role in the catalytic creation of dTDP, DTYMK plays an important role in the pathway of DNA synthesis and is thought to be involved in cell cycle progression and cell growth.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 2mM DTT, 0.1M NaCl.
• Molecular Mass: 26 kDa (232aa), confirmed by MALDI-TOF
• Purity: > 95 % by SDS-PAGE
• Concentration: 1 mg/ml (determined by Bradford assay )
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: DTYMK deoxythymidylate kinase (thymidylate kinase) [ Homo sapiens ]
• Official Symbol: DTYMK
• Synonyms: DTYMK;deoxythymidylate kinase (thymidylate kinase); CDC8; TYMK; TMPK; PP3731; FLJ44192; dTMP kinase; EC 2.7.4.9; Thymidylate kinase; thymidylate kinase; thymidylate (dTMP) kinase; OTTHUMP00000200146; OTTHUMP00000200145; MGC198617
• Gene ID: 1841
• mRNA Refseq: NM_012145
• Protein Refseq: NP_036277
• MIM: 188345
• UniProt ID: P23919
• Chromosome Location: 2q37.3
• Function: ATP binding; kinase activity; nucleoside phosphate kinase activity; nucleotide binding; thymidylate kinase activity; transferase activity