DTYMK
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Official Full Name
deoxythymidylate kinase (thymidylate kinase) -
Overview
Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene. and belongs to thymidylate kinase family of proteins. -
Synonyms
DTYMK;deoxythymidylate kinase (thymidylate kinase);thymidylate kinase;CDC8;dTMP kinase;thymidylate (dTMP) kinase;TMPK;TYMK;PP3731;FLJ44192;MGC198617
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- Insect Cell
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DTYMK involved in several pathways and played different roles in them. We selected most pathways DTYMK participated on our site, such as Metabolic pathways,Metabolism,Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTYMK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of nucleotides | DGUOK,DUT,GRX2,DPYDA.1,UPP2,NUDT18,ADK,NUDT5,NUDT15,NUDT16 |
| Metabolism | PEMT,AGPAT6,ADA,C2orf56,UGT1B4,DHCR24,AK8,COX15,MED10,YAP1 |
| Metabolic pathways | CKB,POLR3GL,ALDOA,MDH1AA,MTHFD2,ackA,CYP2B19,CDA,PLA2G4AA,B3GALT5 |
| pyrimidine deoxyribonucleotide phosphorylation | CMPK2 |
| Synthesis and interconversion of nucleotide di- and triphosphates | AK7,AK8,GLRX,AK7A,GRX2 |
| pyrimidine deoxyribonucleotides de novo biosynthesis | DUT |
| Pyrimidine metabolism | DCK,POLD2,NME1-NME2,POLR2K,POLE4,UCK1,POLR3K,CDA,NME5,DHODH |
Protein Function
DTYMK has several biochemical functions, for example, ATP binding,nucleoside phosphate kinase activity,thymidylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DTYMK itself. We selected most functions DTYMK had, and list some proteins which have the same functions with DTYMK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| uridylate kinase activity | CMPK,CMPK1 |
| thymidylate kinase activity | CMPK2 |
| ATP binding | KIF11,ATP6V1BA,ULK2,PDK1,DHX9,RECQL4,NUBP2,TTK,EPHB6,EHD2 |
| nucleoside phosphate kinase activity | AK9 |
Interacting Protein
DTYMK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTYMK here. Most of them are supplied by our site. Hope this information will be useful for your research of DTYMK.
HSD17B7;CDC5L
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References
- Felizardo, TC; Foley, J; et al. Harnessing autophagy for cell fate control gene therapy. AUTOPHAGY 9:1069-1079(2013).
- Liu, Y; Marks, K; et al. Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer. CANCER DISCOVERY 3:870-879(2013).
