Recombinant Human DR1

• Cat.No.: DR1-28440TH
• Product Overview: Recombinant full length Human DR1; amino acids 1-176, 19kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-176 a.a.
• Description: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
• Biological activity: 1 unit equals 1 nanogram of purified protein.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) [ Homo sapiens ]
• Official Symbol: DR1
• Synonyms: DR1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); protein Dr1; NC2; NC2 BETA
• Gene ID: 1810
• mRNA Refseq: NM_001938
• Protein Refseq: NP_001929
• MIM: 601482
• Uniprot ID: Q01658
• Chromosome Location: 1p22.1
• Function: DNA binding; TBP-class protein binding; protein binding; sequence-specific DNA binding; transcription corepressor activity