DR1
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Official Full Name
down-regulator of transcription 1, TBP-binding (negative cofactor 2) -
Overview
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. -
Synonyms
DR1;down-regulator of transcription 1, TBP-binding (negative cofactor 2);protein Dr1;NC2;NC2 BETA;Dr1 protein;Negative cofactor 2 beta;Downregulator of transcription 1;Down regulator of transcription 1 TBP binding;DR 1;NC 2;Negative co factor 2;Negative cofactor 2;TATA binding protein associated phosphoprotein;OTTHUMP00000012556;OTTHUMP00000012557;negative cofactor 2-beta;TATA-binding protein-associated phosphoprotein;NC2-BETA
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
DR1 involved in several pathways and played different roles in them. We selected most pathways DR1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with DR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HATs acetylate histones | ING5,KAT7A,MORF4L1,PHF20B,KANSL3,PAX3A,EP400,USP22,ING5A,BRPF3 |
| Chromatin organization | KDM5D,PRMT5,KDM6AL,SUZ12,JMJD6,MSL3,SAP130,BRMS1,C20orf20,GATAD2A |
| Chromatin modifying enzymes | AEBP2,DNMT3A,MSL2,SMARCD3B,KDM3B,CCDC101,ATXN7L3,EED,ING5B,C20orf20 |
Protein Function
DR1 has several biochemical functions, for example, DNA binding,TBP-class protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DR1 itself. We selected most functions DR1 had, and list some proteins which have the same functions with DR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | CIR1,SKI,HEYL,NR0B2,HIPK2,HDAC4,RLIM,FOXP3,SSX4,LIMD1 |
| DNA binding | FLI1B,SSH3,LIG1,HNF1B,DEK,UHRF2,NUSAP1,ZNF287,ZNF738,LIN28A |
| protein binding | NPM2,RUSC1,FAM113A,C11orf46,PPP2R3A,C4orf46,PNKD,TMEM30A,MYBPC2,PDE6H |
| transcription factor binding | GATA4,ESRRB,PYDC3,SLC26A5,PRICKLE1,SORBS3,UBN1,PIANP,APBB1,ATOH8 |
| protein heterodimerization activity | H2-AA,ALG2,BCL2,RALGAPA2,BCL2L10,HMG20B,MCL1B,PHC2B,HIST1H4I,SMC4 |
| TBP-class protein binding | PSMC4,THRA,PSMC1B,PSMC3,PSMC6,BRF1,TAF1,CAND2,EFCAB11,BRF1B |
Interacting Protein
DR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DR1.
tbp;NFYC;DRAP1;q7ard3_yerpe;ZDHHC17;POLE3;ssdna_dadts;Sgol2;PARD6B;Cul1
Resources
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References
- Reynolds, CJ; Jones, C; et al. The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles. IMMUNOLOGY 143:438-446(2014).
- Sundqvist, E; Buck, D; et al. JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants. PLOS PATHOGENS 10:-(2014).
