Recombinant Human DPPA4 Protein, GST-tagged

• Cat.No.: DPPA4-2854H
• Product Overview: Human DPPA4 full-length ORF ( AAH32846.2, 1 a.a. - 304 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 59.9 kDa
• AA Sequence: MLRGSASSTSMEKAKGKEWTSTEKSREEDQQASNQPNSIALPGTSAKRTKEKMSVKGSKVLCPKKKAEHTDNPRPQKKIPIPPLPSKLPPVNLIHRDILRAWCQQLKLSSKGQKLDAYKRLCAFAYPNQKDFPSTAKEAKIRKSLQKKLKVEKGETSLQSSETHPPEVALPPVGEPPALENSTALLEGVNTVVVTTSAPEALLASWARISARARTPEAVESPQEASGVRWCVVHGKSLPADTDGWVHLQFHAGQAWVPEKQEGRVSALFLLPASNFPPPHLEDNMLCPKCVHRNKVLIKSLQWE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DPPA4 developmental pluripotency associated 4 [ Homo sapiens ]
• Official Symbol: DPPA4
• Synonyms: DPPA4; developmental pluripotency associated 4; developmental pluripotency-associated protein 4; FLJ10713; 2410091M23Rik
• Gene ID: 55211
• mRNA Refseq: NM_018189
• Protein Refseq: NP_060659
• MIM: 614125
• UniProt ID: Q7L190