Recombinant Human DPH5 Protein, MYC/DDK-tagged

• Cat.No.: DPH5-2477H
• Product Overview: Recombinant Human DPH5 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 31.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DPH5 DPH5 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: DPH5
• Synonyms: AD-018; CGI-30; HSPC143; NPD015
• Gene ID: 51611
• mRNA Refseq: NM_001077394
• Protein Refseq: NP_001070862
• MIM: 611075
• UniProt ID: Q9H2P9