DPH5
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Official Full Name
DPH5 homolog (S. cerevisiae) -
Overview
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DPH5;DPH5 homolog (S. cerevisiae);diphthine synthase;CGI 30;AD 018;AD018;CGI30;Diphthamide biosynthesis methyltransferase;NPD015;Protein x 0011;AD-018;CGI-30;HSPC143
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
DPH5 involved in several pathways and played different roles in them. We selected most pathways DPH5 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Metabolism of proteins,Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gamma carboxylation, hypusine formation and arylsulfatase activation | DPH1,ARSF,SUMF2,DHPS,ARSI,EEF2,PROCA,GAS6,ATPBD4,EIF5A2 |
| Metabolism of proteins | DDOST,CCT6A,GRPEL2,TIMM23,SFTPBB,TRAPPC6B,ATP6AP2,FBXL5,MUC1,GALNTL5 |
| Synthesis of diphthamide-EEF2 | DPH3,WDR85,DNAJC24,DPH2,DPH1,ATPBD4,OTOP2 |
| Post-translational protein modification | GNE,ADAMTSL3,TRAPPC2,CBX4,TRAPPC10,TMED2,ADAMTSL4,MUC1,MGAT4A,EIF5A2 |
| diphthamide biosynthesis | ATPBD4 |
Protein Function
DPH5 has several biochemical functions, for example, diphthine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPH5 itself. We selected most functions DPH5 had, and list some proteins which have the same functions with DPH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
DPH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPH5.
Resources
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References
- Lin, ZW; Su, XY; et al. Dph7 Catalyzes a Previously Unknown Demethylation Step in Diphthamide Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:6179-6182(2014).
- Abdel-Fattah, W; Scheidt, V; et al. Insights into Diphthamide, Key Diphtheria Toxin Effector. TOXINS 5:958-968(2013).
