Recombinant Human DPH2

• Cat.No.: DPH2-28432TH
• Product Overview: Recombinant full length Human DPH2 with a N terminal proprietary tag; Predicted MWt 79.90 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 489 amino acids
• Description: This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.
• Molecular Weight: 79.900kDa inclusive of tags
• Tissue specificity: Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, speen, thymus, prostate, ovary and lymphocytes.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAG FVRDLGCERVALQFPDQLLGDAVAVAARLEETTGSKMFIL GDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPV AFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHA LEALATLLRPRYLDLLVSSPAFPQPVGSLSPEPMPLERFG RRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLG WAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARD ARVVGLLAGTLGVAQHREALAHLRNLTQAAGKRSYVLALG RPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILA PCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPP ESELWETPDVSLITGDLRPPPAWKSSNDHGSLALTPRPQL ELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIA IAYEDEGSG
• Sequence Similarities: Belongs to the DPH1/DPH2 family. DPH2 subfamily.

Gene Information

• Gene Name: DPH2 DPH2 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: DPH2
• Synonyms: DPH2; DPH2 homolog (S. cerevisiae); diptheria toxin resistance protein required for diphthamide biosynthesis like 2 (S. cerevisiae) , DPH2 like 2 (S. cerevisiae) , DPH2L2; diphthamide biosynthesis protein 2
• Gene ID: 1802
• mRNA Refseq: NM_001039589
• Protein Refseq: NP_001034678
• MIM: 603456
• Uniprot ID: Q9BQC3
• Chromosome Location: 1p34