DPH2
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Official Full Name
DPH2 homolog (S. cerevisiae) -
Overview
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DPH2;DPH2 homolog (S. cerevisiae);diptheria toxin resistance protein required for diphthamide biosynthesis like 2 (S. cerevisiae) , DPH2 like 2 (S. cerevisiae) , DPH2L2;diphthamide biosynthesis protein 2;Diphthamide biosynthesis like protein 2;Diphthamide biosynthesis protein 2 homolog like 2;Diphthamide biosynthesis protein 2 homolog-like 2;Diptheria toxin resistance protein required for diphthamide biosynthesis like 2;Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae;DPH 2;DPH2 homolog;DPH2 homolog S. cerevisiae;DPH2 like 2;DPH2 like 2 S. cerevisiae;DPH2-like 2;DPH2_HUMAN;DPH2L2;HsDph2;OTTHUMP00000010007;Protein DPH2 homolog;OTTHUMP00000231247;diphthamide biosynthesis-like protein 2;diptheria toxin resistance protein required for diphthamide biosynthesis-like 2
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&SUMO
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DPH2-1676C | Recombinant Chicken DPH2 | Mammalian Cell | Chicken | His |
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| DPH2-1939R | Recombinant Rat DPH2 Protein | Mammalian Cell | Rat | His |
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| DPH2-2831H | Recombinant Human DPH2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DPH2-28432TH | Recombinant Human DPH2 | Wheat Germ | Human | Non | 489 amino acids |
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| DPH2-4786M | Recombinant Mouse DPH2 Protein | Mammalian Cell | Mouse | His |
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| DPH2-5537Z | Recombinant Zebrafish DPH2 | Mammalian Cell | Zebrafish | His |
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| DPH2-6837HCL | Recombinant Human DPH2 293 Cell Lysate | HEK293 | Human | Non |
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| DPH2-1111H | Recombinant Human DPH2 Protein (1-489 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-489 aa |
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| DPH2-131HF | Recombinant Full Length Human DPH2 Protein | In Vitro Cell Free System | Human | Full L. 489 amino acids |
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| DPH2-1598R | Recombinant Rat DPH2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DPH2-1598R-B | Recombinant Rat DPH2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DPH2-2500M | Recombinant Mouse DPH2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DPH2-2500M-B | Recombinant Mouse DPH2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dph2-2635M | Recombinant Mouse Dph2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DPH2-2839H | Recombinant Human DPH2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| DPH2-4074HF | Recombinant Full Length Human DPH2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 489 amino acids |
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Involved Pathway
DPH2 involved in several pathways and played different roles in them. We selected most pathways DPH2 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Metabolism of proteins,Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synthesis of diphthamide-EEF2 | DPH3,DPH1,OTOP2,ATPBD4,DNAJC24,WDR85,DPH5 |
| Post-translational protein modification | SPON2,SPON1A,CNIH,ANKRD28,NAPAA,DNAJC24,ADAMTS1,WDR85,SAE1,ARSF |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSD,ARSH,ARSF,DPH1,FURINB,EIF5A,ATPBD4,ARSI,OTOP2,GAS6 |
| Metabolism of proteins | SEC16B,TMED2,MBOAT4,SFTPC,CKAP4,FBXW5,ST6GAL2B,DOHH,PAPPA,SFTPBB |
Protein Function
DPH2 has several biochemical functions, for example, 2-(3-amino-3-carboxypropyl)histidine synthase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPH2 itself. We selected most functions DPH2 had, and list some proteins which have the same functions with DPH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SCRN2,TBATA,NOX5,TWF2,GNAT1,RDBP,CTDNEP1,MXI1,CD27,RBM5 |
Interacting Protein
DPH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPH2.
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References
- Pemov, A; Sung, HJ; et al. Genetic Modifiers of Neurofibromatosis Type 1-Associated Cafe-au-Lait Macule Count Identified Using Multi-platform Analysis. PLOS GENETICS 10:-(2014).
- Dong, M; Su, XY; et al. Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:1754-1757(2014).
