Recombinant Human DLL4, Fc-tagged

• Cat.No.: DLL4-26672TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-529 of Human DLL4 fused at the C terminus to the Fc portion of Human IgG1; MWt: 100 kDa by SDS Page.

Specification

• Description: This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
• Protein length: 529 amino acids
• Conjugation: Fc
• Molecular Weight: 100.000kDa inclusive of tags
• Source: HEK 293 cells
• Tissue specificity: Expressed in vascular endothelium.
• Biological activity: Inhibits adipogenesis of 3T3L-1 cells and mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 DSL domain.Contains 8 EGF-like domains.

Gene Information

• Gene Name: DLL4 delta-like 4 (Drosophila) [ Homo sapiens ]
• Official Symbol: DLL4
• Synonyms: DLL4; delta-like 4 (Drosophila); delta like 4 homolog (Drosophila); delta-like protein 4
• Gene ID: 54567
• mRNA Refseq: NM_019074
• Protein Refseq: NP_061947
• MIM: 605185
• Uniprot ID: Q9NR61
• Chromosome Location: 15q14
• Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem; Notch receptor binds with a ligand, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem
• Function: Notch binding; calcium ion binding