Recombinant Human DGKZ, His-tagged

Description :	The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified.
Conjugation :	HIS
Source :	E. coli
Tissue specificity :	Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
Form :	Lyophilised:Reconstitute with 148 μl aqua dest.
Storage buffer :	Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids :	GTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSP KWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILD PELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPP QGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLL HHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTE LAAYLENRQHYQMIQREDQETAV
Sequence Similarities :	Belongs to the eukaryotic diacylglycerol kinase family.Contains 2 ANK repeats.Contains 1 DAGKc domain.Contains 2 phorbol-ester/DAG-type zinc fingers.
Protein length :	641-895 a.a.

Gene Name	DGKZ diacylglycerol kinase, zeta [ Homo sapiens ]
Official Symbol	DGKZ
Synonyms	DGKZ; diacylglycerol kinase, zeta; diacylglycerol kinase, zeta 104kDa; diacylglycerol kinase zeta; DAGK5; DAGK6; DGK ZETA; hDGKzeta;
Gene ID	8525
mRNA Refseq	NM_001199267
Protein Refseq	NP_001186196
MIM	601441
Uniprot ID	Q13574
Chromosome Location	11p11.2
Pathway	Effects of PIP2 hydrolysis, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem;
Function	ATP binding; diacylglycerol kinase activity; diacylglycerol kinase activity; enzyme inhibitor activity; lipid kinase activity;