Active Recombinant Human DGKA protein, GST-tagged

Cat.No. : DGKA-181H
Product Overview : Recombinant Human DGKA fused with GST tag at N-terminal was expressed in Insect cells.
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Species : Human
Source : Insect Cells
Tag : GST
Description : Diacylglycerol kinase alpha (DAG kinase alpha) is a member of the eukaryotic diacylglycerol kinase family. Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resyn-thesis of phosphatidylinositols and attenuating protein kinase C activity. Involved in hepatocellular carcinoma progression through regulation of the Ras/Raf/MEK/ERK pathway. The DGKα/atypical PKC/β1 integrin signaling pathway is required for matrix invasion of breast carcinoma cells.
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 3000 nmol/min/mg
Molecular Mass : 105 kDa
Purity : >90%
Applications : Kinase Assay
Stability : 1 year at -70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name DGKA diacylglycerol kinase, alpha 80kDa [ Homo sapiens ]
Official Symbol DGKA
Synonyms DGKA; diacylglycerol kinase, alpha 80kDa; DAGK, DAGK1, diacylglycerol kinase, alpha (80kD); diacylglycerol kinase alpha; DGK alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase; DAGK; DAGK1; DGK-alpha; MGC12821; MGC42356;
Gene ID 1606
mRNA Refseq NM_001345
Protein Refseq NP_001336
MIM 125855
UniProt ID P23743
Chromosome Location 12q13.3
Pathway Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Glycerophospholipid metabolism, organism-specific biosystem;
Function ATP binding; calcium ion binding; diacylglycerol kinase activity; nucleotide binding; phospholipid binding; transferase activity;

Not For Human Consumption!

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