Active Recombinant Human DGKA protein, GST-tagged
Cat.No. : | DGKA-181H |
Product Overview : | Recombinant Human DGKA fused with GST tag at N-terminal was expressed in Insect cells. |
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Species : | Human |
Source : | Insect Cells |
Tag : | GST |
Description : | Diacylglycerol kinase alpha (DAG kinase alpha) is a member of the eukaryotic diacylglycerol kinase family. Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resyn-thesis of phosphatidylinositols and attenuating protein kinase C activity. Involved in hepatocellular carcinoma progression through regulation of the Ras/Raf/MEK/ERK pathway. The DGKα/atypical PKC/β1 integrin signaling pathway is required for matrix invasion of breast carcinoma cells. |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 3000 nmol/min/mg |
Molecular Mass : | 105 kDa |
Purity : | >90% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name | DGKA diacylglycerol kinase, alpha 80kDa [ Homo sapiens ] |
Official Symbol | DGKA |
Synonyms | DGKA; diacylglycerol kinase, alpha 80kDa; DAGK, DAGK1, diacylglycerol kinase, alpha (80kD); diacylglycerol kinase alpha; DGK alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase; DAGK; DAGK1; DGK-alpha; MGC12821; MGC42356; |
Gene ID | 1606 |
mRNA Refseq | NM_001345 |
Protein Refseq | NP_001336 |
MIM | 125855 |
UniProt ID | P23743 |
Chromosome Location | 12q13.3 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Glycerophospholipid metabolism, organism-specific biosystem; |
Function | ATP binding; calcium ion binding; diacylglycerol kinase activity; nucleotide binding; phospholipid binding; transferase activity; |
◆ Cell & Tissue Lysates | ||
DGKA-6961HCL | Recombinant Human DGKA 293 Cell Lysate | +Inquiry |
DGKA-6960HCL | Recombinant Human DGKA 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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