Recombinant Human DGKA

• Cat.No.: DGKA-26771TH
• Product Overview: Recombinant full length Human DGKA with N terminal proprietary tag; Predicted MWt 106.96 kDa including the tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 735 amino acids
• Description: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
• Molecular Weight: 106.960kDa inclusive of tags
• Tissue specificity: Lymphocytes and oligodendroglial cells.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMA KYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFET GHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPIL QEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTL KDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESG RCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQAVGHECD CGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYI LNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGGDGTVGW ILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQI INNYFSIGVDASIAHRFYIMREKYPEKFNSRMKNKLWYFE FATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPD ILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLA KCSEITFHTTKTLPMQIDGEPWVQTPCTIKITHKNQMPML MGPPPRSTNFFGFLS
• Sequence Similarities: Belongs to the eukaryotic diacylglycerol kinase family.Contains 1 DAGKc domain.Contains 2 EF-hand domains.Contains 2 phorbol-ester/DAG-type zinc fingers.

Gene Information

• Gene Name: DGKA diacylglycerol kinase, alpha 80kDa [ Homo sapiens ]
• Official Symbol: DGKA
• Synonyms: DGKA; diacylglycerol kinase, alpha 80kDa; DAGK, DAGK1, diacylglycerol kinase, alpha (80kD); diacylglycerol kinase alpha; DGK alpha
• Gene ID: 1606
• mRNA Refseq: NM_001345
• Protein Refseq: NP_001336
• MIM: 125855
• Uniprot ID: P23743
• Chromosome Location: 12q13.3
• Pathway: Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Effects of PIP2 hydrolysis, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Glycerolipid metabolism, organism-specific biosystem
• Function: ATP binding; calcium ion binding; diacylglycerol kinase activity; nucleotide binding; phospholipid binding