Recombinant Human DEK Protein, GST-tagged

• Cat.No.: DEK-2529H
• Product Overview: Human DEK full-length ORF (BAG35503.1, 1 a.a. - 375 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 67.65 kDa
• AA Sequence: MSASAPAAEGEGTPTQPASEKEPEM PGPREESEEEEDEDDEEEEEEEKEK SLIVEGKREKKKVERLTMQVSSLQR EPFTIAQGKGQKLCEIERIHFFLSK KKTDELRNLHKLLYNRPGTVSSLKK NVGQFSGFPFEKGSVQYKKKEEMLK KFRNAMLKSICEVLDLERSGVNSEL VKRILNFLMHPKPSGKPLPKSKKTC SKGSKKERNSSGMARKAKRTKCPEI LSDESSSDEDEKKNKEESSDDEDKE SEEEPPKKTAKREKPKQKATSKSKK SVKSANVKKADSSTTKKNQNSSKKE SESEDSSDDEPLIKKLKKPPTDEEL KETIKKLLASANLEEVTMKQICKKV YENYPTYDLTERKDFIKTTVKELIS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DEK DEK oncogene [ Homo sapiens ]
• Official Symbol: DEK
• Synonyms: DEK; DEK oncogene; DEK oncogene (DNA binding); protein DEK; D6S231E
• Gene ID: 7913
• mRNA Refseq: NM_001134709
• Protein Refseq: NP_001128181
• MIM: 125264
• UniProt ID: P35659

Reviews

08/27/2021

This collaboration may extend beyond the purchase of the DEK protein, potentially leading to additional support, joint research projects, or access to expertise in the field.

12/20/2019

This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.

08/13/2016

The manufacturer can provide researchers with high-quality DEK protein, ensuring it is properly purified, characterized, and quality-controlled.

Q&As

What are the current diagnostic methods for assessing DEK protein levels in clinical samples?

Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry are commonly used to measure DEK protein levels in clinical samples from cancer and autoimmune disease patients.

How does DEK protein contribute to the pathogenesis of autoimmune diseases?

DEK protein has been shown to play a role in aberrant immune responses, leading to the development of autoimmune diseases such as lupus and rheumatoid arthritis.

How does DEK protein interact with other cellular proteins in cancer and autoimmune diseases?

DEK protein has been shown to interact with various cellular proteins, modulating signaling pathways and gene expression patterns associated with cancer and autoimmune diseases.

Are there any specific genetic mutations associated with DEK protein dysregulation in cancer?

Mutations in the DEK gene and its regulatory regions have been identified in certain cancers, contributing to its aberrant expression and oncogenic potential.

Can DEK protein levels in patient samples predict treatment response in cancer therapy?

Studies have suggested that DEK protein levels in patient samples may serve as predictive biomarkers for treatment response and resistance in cancer therapy.