Recombinant Human DCXR, His-tagged

Cat.No. : DCXR-26175TH
Product Overview : Recombinant full length Human DCXR (amino acids 1-244) with N terminal His tag; 264 amino acids, 28kDa.
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Species : Human
Source : E.coli
Tag : His
Protein Length : 244 amino acids
Description : The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.
Conjugation : HIS
Molecular Weight : 28.000kDa inclusive of tags
Tissue specificity : Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 0.29% Sodium chloride, 20% Glycerol
Storage : Store at -20°C (dessicate conditions).
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
Sequence Similarities : Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Gene Name DCXR dicarbonyl/L-xylulose reductase [ Homo sapiens ]
Official Symbol DCXR
Synonyms DCXR; dicarbonyl/L-xylulose reductase; L-xylulose reductase; DCR; KIDCR; SDR20C1; short chain dehydrogenase/reductase family 20C; member 1;
Gene ID 51181
mRNA Refseq NM_001195218
Protein Refseq NP_001182147
MIM 608347
Uniprot ID Q7Z4W1
Chromosome Location 17q25.3
Pathway Metabolic pathways, organism-specific biosystem; Pentose and glucuronate interconversions, organism-specific biosystem; Pentose and glucuronate interconversions, conserved biosystem;
Function L-xylulose reductase (NADP+) activity; nucleotide binding; oxidoreductase activity, acting on CH-OH group of donors;

Not For Human Consumption!

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