Recombinant Human DCK, His-tagged

• Cat.No.: DCK-796H
• Product Overview: Recombinant Human DCK, fused with N-terminal polyhistidine tag, was expressed in Sf9 cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
• Molecular Mass: 30 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Gene Information

• Gene Name: DCK deoxycytidine kinase [ Homo sapiens (human) ]
• Official Symbol: DCK
• Synonyms: DCK; deoxycytidine kinase; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119; EC 2.7.1.74
• Gene ID: 1633
• mRNA Refseq: NM_000788
• Protein Refseq: NP_000779
• MIM: 125450
• UniProt ID: P27707
• Chromosome Location: 4q13.3-q21.1
• Pathway: Purine metabolism; Pyrimidine metabolism
• Function: ATP binding; deoxycytidine kinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity