Recombinant Human DAPK3, GST-tagged, Active

• Cat.No.: DAPK3-291H
• Product Overview: Recombinant human full-length DAPK3 was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW= 79kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: DAPK3 or Death-associated protein kinase 3 (also known as ZIP) plays a role in apoptosis. DAPK3 is a nuclear serine/threonine-specific kinase that phosphorylates core histones H3 and H4, and myosine light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4 suggesting that it participates in multiple cellular processes. DAPK3 contains a leucine zipper structure at its C terminus and this region is responsible for binding to ATF4. The leucine zipper domain is necessary for the homodimerization of DAPK3 as well as for the activation of the kinase.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: DAPK3 death-associated protein kinase 3 [ Homo sapiens ]
• Synonyms: DAPK3; death-associated protein kinase 3; ZIP; ZIPK; FLJ36473; ZIP kinase isoform; EC 2.7.11.1; ZIP-kinase
• Gene ID: 1613
• mRNA Refseq: NM_001348
• Protein Refseq: NP_001339
• MIM: 603289
• UniProt ID: O43293
• Chromosome Location: 19p13.3
• Pathway: Bladder cancer; Pathways in cancer
• Function: ATP binding; calmodulin binding; nucleotide binding ; protein serine/threonine kinase activity transferase activity