DAPK3
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Official Full Name
death-associated protein kinase 3 -
Overview
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells.These results suggest that DAPK3 may play a role in the induction of apoptosis. -
Synonyms
DAPK3;death-associated protein kinase 3;ZIP;ZIPK;dlk;ZIP-kinase;DAP kinase 3;MYPT1 kinase;DAP-like kinase;ZIP kinase isoform;zipper-interacting protein kinase;FLJ36473
Recombinant Proteins
- Rhesus macaque
- Mouse
- Rat
- Human
- Mammalian Cells
- E.coli
- Insect Cells
- Wheat Germ
- Sf9 Cells
- Human
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- His
- His&T7
- GST
- Non
- Avi&Fc&His
- DDK&Myc
- Flag
Involved Pathway
DAPK3 involved in several pathways and played different roles in them. We selected most pathways DAPK3 participated on our site, such as Apoptosis,Bladder cancer,Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bladder cancer | CXCL8,RB1,THBS1,HBEGF,TRP53,UPK3A,ERBB2,MAPK3,ARAF,E2F2 |
| Programmed Cell Death | BMX,STK24,DIABLOA,DBNLA,RNF8,STK24A,GZMF,DIABLOB,RIPK3,VIML |
| Ligand-independent caspase activation via DCC | RNF8,DAPK1 |
| Caspase activation via extrinsic apoptotic signalig pathway | RNF8,TICAM1,DAPK1,DCC,CASP8L1 |
| Apoptosis | CASP3A,PRKACG,TNFRSF10C,PRKACAA,PKP1,DAPK1,DFFB,TNFRSFA,PPP3CA,IL3RA |
| Pathways in cancer | PIK3CG,LPAR5,LAMC2,FLT3,ERBB2,FGF21,RAF1,CXCL12,VEGFC,GNGT2 |
Protein Function
DAPK3 has several biochemical functions, for example, ATP binding,Rho GTPase binding,cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK3 itself. We selected most functions DAPK3 had, and list some proteins which have the same functions with DAPK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| leucine zipper domain binding | AATF,NRL,ERC1,PMF1,PAWR,DDIT3,CRX,KCNA3,MKL1,ATF4 |
| protein serine/threonine kinase activity | RIOK2,PRKACBB,CAMK1DB,SGK3,TSSK1,TNK2,VPRBP,C9orf96,SQSTM1,CSNK1A1 |
| protein binding | WASH1,LAMA4,SYTL4,ADAMTSL5,ISG20L2,TUBA4A,CAMK2A,APBB1IP,POLDIP2,FAM195B |
| Rho GTPase binding | DIAPH1,INF2,ROCK2B,CSDA,CDC42BPB,PFN1,DAAM1B,ROCK2,DIAP3,IQGAP3 |
| identical protein binding | FTL,NELL2,CD247,VPS4B,LYZ,CNTN2,OMG,VWA1,ADIPOR2,DYNLT1B |
| protein homodimerization activity | CHKA,CEACAM5,PARK7,LILRB1,MASP1,KYNU,SP1,VEGFB,BLOC1S6,GSTM3 |
| ATP binding | CDKL1,DYNC2H1,RAD51L3,VMHC,PTK2BB,CHEK2,PRKD3,ITPKC,PKMYT1,PDK4 |
| cAMP response element binding protein binding | CREM,DDIT3,KCNA3,CRTC3,CRTC1,CREB3,CRTC1A,ATF2,CRTC2 |
Interacting Protein
DAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK3.
TCP10L;PPP1R12A;MYL12B;Daxx;HSP90AB1;ATF4;STAT3;Rhod;CDC37
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References
- Marina, O; Hainz, U; et al. Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens. CANCER RESEARCH 70:1344-1355(2010).
