Recombinant Human Cytokeratin-18 , His-tagged

• Cat.No.: KRT18-266H
• Product Overview: RecombinantHuman human CK-18 is expressed in E. coli with an amino-terminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Tissue polypeptide specific antigen was first identified as a tumour marker in the late 1950's, and has recently been shown to be closely related to human cytokeratin 18. Cytokeratins are a group of about 20 cytoskeletal proteins, whose degradation gives rise to soluble fragments, measurable in the blood of patients. Serum levels are high in breast cancer patients and also some other malignancies, probably due to high cell turnover in tumours.
• Purity: >95% by SDS-PAGE
• Form: Liquid
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: KRT18 keratin 18 [ Homo sapiens ]
• Synonyms: KRT18; CYK18; K18; KRT18; keratin 18; cytokeratin 18; cell proliferation-inducing protein 46; CK-18; Cytokeratin-18; Keratin-18; Cell proliferation-inducing gene 46 protein.
• Gene ID: 3875
• mRNA Refseq: NM_000224
• Protein Refseq: NP_000215
• MIM: 148070
• UniProt ID: P05783
• Chromosome Location: 12q13
• Pathway: Cell Communication; Pathogenic Escherichia coli infection – EHEC; Pathogenic Escherichia coli infection - EPEC
• Function: protein binding; structural molecule activity