Recombinant Human CYR61, His-tagged

• Cat.No.: CYR61-27830TH
• Product Overview: Recombinant fragment corresponding to amino acids 275-381 of Human CCN1 fused to His tag, 17kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 275-381 a.a.
• Description: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
• Conjugation: HIS
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 1X PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.

Gene Information

• Gene Name: CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens ]
• Official Symbol: CYR61
• Synonyms: CYR61; cysteine-rich, angiogenic inducer, 61; IGFBP10; protein CYR61; CCN1; GIG1
• Gene ID: 3491
• mRNA Refseq: NM_001554
• Protein Refseq: NP_001545
• MIM: 602369
• Uniprot ID: O00622
• Chromosome Location: 1p22.3
• Pathway: Hypertrophy Model, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; RhoA signaling pathway, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem
• Function: extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding