Recombinant Human CYP2F1, GST-tagged

• Cat.No.: CYP2F1-11776H
• Product Overview: Recombinant Human CYP2F1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 142-302a.a.
• Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 [ Homo sapiens ]
• Official Symbol: CYP2F1
• Synonyms: CYPIIF1; Cytochrome P450 2F1; cytochrome P450, family 2, subfamily F, polypeptide 1; EC=1.14.14.1; flavoprotein-linked monooxygenase; CYPIIF1; microsomal monooxygenase; EC 1.14.14.1; xenobiotic monooxygenase
• Gene ID: 1572
• mRNA Refseq: NM_000774.3
• Protein Refseq: NP_000765.2
• MIM: 124070
• UniProt ID: P24903
• Chromosome Location: 19q13.2
• Pathway: Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem; Phase 1 - Functionalization of compounds, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem
• Function: aromatase activity; electron carrier activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and