Recombinant Human Cyclin D1, GST-tagged

• Cat.No.: CCND1-1444H
• Product Overview: Recombinant full-length human CyclinD1 was expressed inE. colicells using an N-terminal GST tag. MW = 61 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: CyclinD1 is a member of the cyclin family of proteins that are important regulators cyclin-dependent protein kinases (CDKs). CyclinD1 forms a complex and functions as a regulatory subunit of CDK4 or CDK6 which are important during cell cycle G1/S transition. CyclinD1 has been shown to interact with the tumor suppressor protein Rb and the expression of CyclinD1 is positively regulated by Rb. Mutations, amplification and overexpression of CyclinD1 have been frequently observed in a variety of tumors and suggesting a role of this protein in tumorigenesis.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CCND1 cyclin D1 [ Homo sapiens ]
• Synonyms: CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
• Gene ID: 595
• mRNA Refseq: NM_053056
• Protein Refseq: NP_444284
• MIM: 168461
• UniProt ID: P24385
• Chromosome Location: 11q13
• Pathway: Acute myeloid leukemia; Bladder cancer; Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Endometrial cancer; Focal adhesion; Glioma; Jak-STAT signaling pathway; Melanoma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway; p53 signaling pathway
• Function: cyclin-dependent protein kinase regulator activity; protein complex binding; protein kinase activity; protein kinase binding