Recombinant Human CTTN protein, DDK-tagged
Cat.No. : | CTTN-29H |
Product Overview : | Recombinant Human CTTN, transcript variant 2, fused with DDK tag at C-terminal was expressed in Insect cells. |
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Species : | Human |
Source : | Insect Cells |
Tag : | Flag |
Description : | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. |
Form : | 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. |
Molecular Mass : | 57.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name | CTTN cortactin [ Homo sapiens ] |
Official Symbol | CTTN |
Synonyms | CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin; amplaxin; 1110020L01Rik; oncogene EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); EMS1; FLJ34459; |
Gene ID | 2017 |
mRNA Refseq | NM_138565 |
Protein Refseq | NP_612632 |
MIM | 164765 |
UniProt ID | Q14247 |
Chromosome Location | 11q13 |
Pathway | Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem; Pathogenic Escherichia coli infection, conserved biosystem; |
Function | protein binding; |
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Not For Human Consumption!
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