Recombinant Human CTGF
Cat.No. : | CTGF-28023TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 253-350 of Human CTGF, a 11.2 kDa protein of 98 amino acid residues which exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. |
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Description : | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. |
Source : | E. coli |
Tissue specificity : | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
Biological activity : | Biological Activity : Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml. |
Form : | Lyophilised |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Spin down vial and reconstitute in distilled water for a concentration of 0.1 - 1.0 mg/ml. |
Storage : | The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. |
Sequences of amino acids : | MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA |
Sequence Similarities : | Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain. |
Tag : | Non |
Protein length : | 253-350 a.a. |
Gene Name | CTGF connective tissue growth factor [ Homo sapiens ] |
Official Symbol | CTGF |
Synonyms | CTGF; connective tissue growth factor; CCN2; IGFBP8; |
Gene ID | 1490 |
mRNA Refseq | NM_001901 |
Protein Refseq | NP_001892 |
MIM | 121009 |
Uniprot ID | P29279 |
Chromosome Location | 6q23.2 |
Pathway | Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem; |
Function | fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding; |
Not For Human Consumption!
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