Recombinant Human CSNK1E

• Cat.No.: CSNK1E-27754TH
• Product Overview: Full length recombinant Human CK1 epsilon with N-terminal proprietary tag, 72kDa.

Specification

• Description: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
• Protein length: 416 amino acids
• Molecular Weight: 72.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
• Biological activity: The Specific activity of CSNK1E-27754TH was determined to be 46 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Contains 1 protein kinase domain.
• Tag: Non

Gene Information

• Gene Name: CSNK1E casein kinase 1, epsilon [ Homo sapiens ]
• Official Symbol: CSNK1E
• Synonyms: CSNK1E; casein kinase 1, epsilon; casein kinase I isoform epsilon; HCKIE
• Gene ID: 1454
• mRNA Refseq: NM_001894
• Protein Refseq: NP_001885
• MIM: 600863
• Uniprot ID: P49674
• Chromosome Location: 22q13.1
• Pathway: Canonical Wnt signaling pathway, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian rhythm - mammal, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity